Publications

Overview of chromatin regulatory processes during surface ectodermal development and homeostasis

Meagan C. Branch, Madison Weber, Meng-Yen Li, Pooja Flora, Elena Ezhkova.

Dev Bio 2024, 515, 30-45. doi:10.1016/j.ydbio.2024.07.001

Tenascin-C expressing touch dome keratinocytes exhibit characteristics of all epidermal lineages

Minh Binh Nguyen, Pooja Flora, Meagan C Branch, Madison Weber, Xiang Yu Zheng, Unnikrishnan Sivan, Simon Joost, Karl Annusver, Deyou Zheng, Maria Kasper, Elena Ezhkova

Sci Adv 2024, 10(3), eadi5791. doi:10.1126/sciadv.adi5791

Defining the fate trajectory of eccrine gland formation

Meagan C Branch, Elena Ezhkova

Dev Cell 2024, 59(1), 1-3. doi: 10.1016/j.devcel.2023.12.004

Updates in SJS/TEN: collaboration, innovation, and community

Madeline E Marks, et. al.

Front Med (Lausanne) 2023 10, 1213889. doi: 10.3389/fmed.2023.1213889

Cleavage Under Targets & Release Using Nuclease (CUT&RUN) of Histone Modifications in Epidermal Stem Cells of Adult Murine Skin

Pooja Flora, Elena Ezhkova.

Methods Mol Bio 2024, 2736, 9-21. doi:10.1007/7651_2023_499

Merkel Cell Polyomavirus-mediated reprorgramming in adult Merkel cell progenitors.

Madison Weber, Minh Nguyen, Meng-Yen Li, Pooja Flora, Masahiro Shuda, Elena Ezhkova.

Journ Invest Derm 2023, 143(11), 2163-76. doi: 10.1016/j.jid.2023.04.031

Methyltransferase-independent function of enhancer of zeste homologue 2 maintains tumorigenicity induced by human oncogenic papillomavirus and polyomavirus

Michelle Khattri, Yutaka Amako, Julia R Gibbs, Joseph L Collura, Reety Arora, Alexis Harold, Meng Yen Li, Paul W Harms, Elena Ezhkova, Masahiro Shuda

Tumour Virus Research 2023, 16(200264). doi: 10.1016/j.tvr.2023.200264

Screenshot 2021-12-26 at 15-27-05 pgen_cover_November_2021 pdf.png

Polycomb repressive complex 2 in adult hair follicle stem cells is dispensable for hair regeneration

Pooja Flora, Meng-Yen Li, Phillip M. Galbo Jr., Maider Astorkia, Deyou Zheng, and Elena Ezhkova.

PLoS Genet 2021, 17(12), e1009948. doi: 10.1371/journal.pgen.1009948

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Polycomb Repressive Complex(es) and Their Role in Adult Stem Cells

Pooja Flora, Gil Dalal, Idan Cohen, and Elena Ezhkova

Genes 2021, 12(10), 1485. doi: 10.3390/genes12101485

UV-induced reduction in Polycomb repression promotes epidermal pigmentation

Meng-Yen Li, Pooja Flora, Hong Pu, Carmit Bar, Jose Silva, Idan Cohen, Phillip M Galbo Jr, Hequn Liu 5, Xufen Yu, Jian Jin, Haruhiko Koseki, John A D'Orazio, Deyou Zheng, Elena Ezhkova

Dev Cell. 2021 Aug 30;S1534-5807(21)00636-5. doi: 10.1016/j.devcel.2021.08.006.

Polycomb complexes redundantly maintain epidermal stem cell identity during development

Idan Cohen, Carmit Bar, Hequn Liu, Victor J Valdes, Dejian Zhao, Phillip M Galbo Jr, Jose M Silva, Haruhiko Koseki, Deyou Zheng, Elena Ezhkova

Genes Dev, 18 Feb 2021, doi: 10.1101/gad.345363.120

Regulatory mechanisms governing epidermal stem cell function during development and homeostasis

Pooja Flora, Elena Ezhkova

Development, Nov 15, 2020; 147(22):dev194100. doi: 10.1242/dev.194100.

Chromatin Immunoprecipitation of Low Number of FACS-Purified Epidermal Cells

Bar C, Valdes VJ, Ezhkova E.

Methods Mol Biol. 2020;2154:197-215. doi: 10.1007/978-1-0716-0648-3_17

Activity of PRC1 and Histone H2AK119 Monoubiquitination: Revising Popular Misconceptions

Cohen I, Bar C, Ezhkova E.

Bioessays. 2020 Mar 20:e1900192. doi: 10.1002/bies.201900192

Conversion of Sox2-dependent Merkel cell carcinoma to a differentiated neuron-like phenotype by T antigen inhibition

Harold A, Amako Y, Hachisuka J, Bai Y, Li MY, Kubat L, Gravemeyer J, Franks J, Gibbs JR, Park HJ, Ezhkova E, Becker JC, Shuda M

Proc Natl Acad Sci U S A. 2019 Sep 16. pii: 201907154. doi: 10.1073/pnas.1907154116

Polycomb Repressive Complex 1 Controls Maintenance of Fungiform Papillae by Repressing Sonic Hedgehog Expression

Bar C, Cohen I, Zhao D, Pothula V, Litskevitch A, Koseki H Zheng D, Ezhkova E.

Cell Rep. 2019 Jul 2;28(1):257-266.e5. doi: 10.1016/j.celrep.2019.06.011

Epigenetic gene regulation, chromatin structure, and force-induced chromatin remodelling in epidermal development and homeostasis

Miroshnikova YA, Cohen I, Ezhkova E, Wickström SA.

Curr Opin Genet Dev. 2019 May 18;55:46-51. doi: 10.1016/j.gde.2019.04.014

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Dissection of Merkel cell formation in hairy and glabrous skin reveals a common requirement for FGFR2-mediated signaling

Nguyen MB, Valdes VJ, Cohen I, Pothula V, Zhao D, Zheng D, Ezhkova E.

Exp Dermatol. 2019 Feb 13. doi: 10.1111/exd.13901

PRC1 preserves epidermal tissue integrity independently of PRC2

Cohen I, Zhao D, Menon G, Nakayama M, Koseki H, Zheng D, Ezhkova E.

Genes Dev. 2018 Dec 19. doi: 10.1101/gad.319939.118

FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells

Nguyen MB, Cohen I, Kumar V, Xu Z, Bar C, Dauber-Decker KL, Tsai PC, Marangoni P, Klein OD, Hsu YC, Chen T, Mikkola ML, Ezhkova E.

Nat Commun. 2018 Jun 13;9(1):2333. doi: 10.1038/s41467-018-04399-y.

PMID: 29899403

PRC1 Fine-tunes Gene Repression and Activation to Safeguard Skin Development and Stem Cell Specification

Cohen I, Zhao D, Bar C, Valdes VJ, Dauber-Decker KL, Nguyen MB1, Nakayama M, Rendl M, Bickmore WA, Koseki H, Zheng D, Ezhkova E

Cell Stem Cell. 2018 May 3;22(5):726-739.e7. doi: 10.1016/j.stem.2018.04.005.

PMID: 29727681

miR-424(322)/503 is a breast cancer tumor suppressor whose loss promotes resistance to chemotherapy

Rodriguez-Barrueco R1,2, Nekritz EA1, Bertucci F3, Yu J4, Sanchez-Garcia F5, Zeleke TZ1, Gorbatenko A1, Birnbaum D3, Ezhkova E6, Cordon-Cardo C1, Finetti P3, Llobet-Navas D1,2, Silva JM1

Genes Dev. 2017 Mar 15;31(6):553-566. doi: 10.1101/gad.292318.116

PMID:28404630

Hair follicles' transit-amplifying cells govern concurrent dermal adipocyte production through Sonic Hedgehog

Zhang B, Tsai PC, Gonzalez-Celeiro M, Chung O, Boumard B, Perdigoto CN, Ezhkova E, Hsu YC.

Genes Dev. 2016 Oct 15;30(20):2325-2338. Epub 2016 Nov 2.

PMID: 27807033

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Polycomb-Mediated Repression and Sonic Hedgehog Signaling Interact to Regulate Merkel Cell Specification during Skin Development

Perdigoto CN, Dauber KL, Bar C, Tsai PC, Valdes VJ, Cohen I, Santoriello FJ, Zhao D, Zheng D, Hsu YC, Ezhkova E

PLoS Genet. 2016 Jul 14;12(7):e1006151. doi: 10.1371/journal.pgen.1006151. eCollection 2016 Jul

PMID:27414999

The mesenchymal transcription factor SNAI-1 instructs human liver specification

Goldman O, Valdes VJ, Ezhkova E Gouon-Evans V

Stem Cell Res. 2016 Jul;17(1):62-8. doi: 10.1016/j.scr.2016.05.007. Epub 2016 May 21.

PMID:27240252

Molecular Mechanisms Regulating Stem Cells Fate

Chen YG, Ezhkova E, Ostankovitch M.

J Mol Biol. 2016 Apr 10;428(7):1407-8. doi: 10.1016/j.jmb.2016.03.011. Epub 2016 Mar 18

PMID:26996938

Dissecting the Roles of Polycomb Repressive Complex 2 Subunits in the Control of Skin Development

Dauber KL, Perdigoto CN, Valdes VJ, Santoriello FJ, Cohen I, Ezhkova E.

J Invest Dermatol. 2016 Aug;136(8):1647-55. doi: 10.1016/j.jid.2016.02.809. Epub 2016 Mar 16.

PMID:26994968

Cbx4: A new guardian of p63's domain of epidermal control.

Cohen I, Ezhkova E

J Cell Biol. 2016 Jan 4;212(1):9-11. doi: 10.1083/jcb.201512032. Epub 2015 Dec 28

PMID:26711501

Terminal epidermal differentiation is regulated by the interaction of Fra-2/AP-1 with Ezh2 and ERK1/2

Wurm S, Zhang J, Guinea-Viniegra J, García F, Muñoz J, Bakiri L, Ezhkova E, Wagner EF

Genes Dev. 2015 Jan 15;29(2):144-56. doi: 10.1101/gad.249748.114. Epub 2014 Dec 29

PMID:25547114

Embryonic maturation of epidermal Merkel cells is controlled by a redundant transcription factor network

Perdigoto CN, Bardot ES, Valdes VJ, Santoriello FJ, Ezhkova E

Development. 2014 Dec;141(24):4690-6. doi: 10.1242/dev.112169

PMID:25468937

The microRNA 424/503 cluster reduces CDC25A expression during cell cycle arrest imposed by transforming growth factor β in mammary epithelial cells

Llobet-Navas D, Rodriguez-Barrueco R, de la Iglesia-Vicente J, Olivan M, Castro V, Saucedo-Cuevas L, Marshall N, Putcha P, Castillo-Martin M, Bardot E, Ezhkova E, Iavarone A, Cordon-Cardo C, Silva JM.

Mol Cell Biol. 2014 Dec 1;34(23):4216-31. doi: 10.1128/MCB.00611-14. Epub 2014 Sep 29

PMID:25266660

The miR-424(322)/503 cluster orchestrates remodeling of the epithelium in the involuting mammary gland

Llobet-Navas D, Rodríguez-Barrueco R, Castro V, Ugalde AP, Sumazin P, Jacob-Sendler D, Demircan B, Castillo-Martín M, Putcha P, Marshall N, Villagrasa P, Chan J, Sanchez-Garcia F, Pe'er D, Rabadán R, Iavarone A, Cordón-Cardó C, Califano A, López-Otín C, Ezhkova E, Silva JM

Genes Dev. 2014 Apr 1;28(7):765-82. doi: 10.1101/gad.237404.114. Epub 2014 Mar 17

PMID:24636986

Epigenetic regulation of epidermal differentiation

Perdigoto CN, Valdes VJ, Bardot ES, Ezhkova E.

Cold Spring Harb Perspect Med. 2014 Feb 1;4(2). pii: a015263. doi: 10.1101/cshperspect.a015263

PMID:24492849

Polycomb subunits Ezh1 and Ezh2 regulate the Merkel cell differentiation program in skin stem cells

Bardot ES, Valdes VJ, Zhang J, Perdigoto CN, Nicolis S, Hearn SA, Silva JM, Ezhkova E.

EMBO J. 2013 Jul 17;32(14):1990-2000. doi: 10.1038/emboj.2013.110. Epub 2013 May 14

PMID:23673358

SWItching on epidermal cell fate

Perdigoto CN1, Bardot ES, Ezhkova E.

Cell Stem Cell. 2013 Feb 7;12(2):141-2. doi: 10.1016/j.stem.2013.01.011.

PMID:23395438

Epigenetic regulation of skin: focus on the Polycomb complex

Perdigoto CN, Valdes VJ, Bardot ES, Ezhkova E

Cell Mol Life Sci. 2012 Jul;69(13):2161-2172. doi: 10.1007/s00018-012-0920-x

PMID:22314499

Histone H2B ubiquitylation and H3 lysine 4 methylation prevent ectopic silencing of euchromatic loci important for the cellular response to heat

Leung A, Cajigas I, Jia P, Ezhkova E, Brickner JH, Zhao Z, Geng F, Tansey WP.

Mol Biol Cell. 2011 Aug 1;22(15):2741-53. doi: 10.1091/mbc.E11-05-0426. Epub 2011 Jun 16.

PMID:21680712

EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair

Ezhkova E, Lien WH, Stokes N, Pasolli HA, Silva JM, Fuchs E.

Genes Dev. 2011 Mar 1;25(5):485-98. doi: 10.1101/gad.2019811. Epub 2011 Feb 11

PMID:21317239

Regenerative medicine: An eye to treating blindness

Ezhkova E, Fuchs E.

Nature. 2010 Jul 29;466(7306):567-8. doi: 10.1038/466567a

PMID:20671696

Cyfip1 is a putative invasion suppressor in epithelial cancers

Silva JM1, Ezhkova E, Silva J, Heart S, Castillo M, Campos Y, Castro V, Bonilla F, Cordon-Cardo C, Muthuswamy SK, Powers S, Fuchs E, Hannon GJ.

Cell. 2009 Jun 12;137(6):1047-61. doi: 10.1016/j.cell.2009.04.013.

PMID:19524508

Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells

Ezhkova E, Pasolli HA, Parker JS, Stokes N, Su IH, Hannon G, Tarakhovsky A, Fuchs E.

Cell. 2009 Mar 20;136(6):1122-35. doi: 10.1016/j.cell.2008.12.043.

PMID:19303854

Chromatin immunoprecipitation to study protein-DNA interactions in budding yeast

Ezhkova E1, Tansey WP.

Methods Mol Biol. 2006;313:225-44.

PMID:16118437

The proteasome regulatory particle alters the SAGA coactivator to enhance its interactions with transcriptional activators

Lee D, Ezhkova E, Li B, Pattenden SG, Tansey WP, Workman JL

Cell. 2005 Nov 4;123(3):423-36.